Sections from spinal cord lesions at 6-weeks after lysolecithin injection were evaluated for myeloid cell abundance by use of the EGFP marker green and immunolabeling for Iba-1 blue. In the absence of macrophage recruitment, OPC proliferation is greatly impaired, again leading to decreased generation of myelinating oligodendrocytes. This article has been cited by. Neural Regen Res ; Two types of CSPG4 manipulations have been used to study the roles of these cells in myelin damage and repair: One hundred percent myelination is defined by the level of MBP labeling in sham-operated control mice.
|License:||For Personal Use Only|
|iPhone 5, 5S resolutions||640×1136|
|iPhone 6, 6S resolutions||750×1334|
|iPhone 7, 7 Plus, 8, 8 Plus resolutions||1080×1920|
|Android Mobiles HD resolutions||360×640, 540×960, 720×1280|
|Android Mobiles Full HD resolutions||1080×1920|
|Mobiles HD resolutions||480×800, 768×1280|
|Mobiles QHD, iPhone X resolutions||1440×2560|
|HD resolutions||1280×720, 1366×768, 1600×900, 1920×1080, 2560×1440, Original|
Sitemap What’s New Feedback Disclaimer. A—C Tissue sections were immunolabeled for myelin basic protein MBP, green and neurofilament protein NF, blueallowing visualization of myelinated axons and axons lacking association with myelin arrows.
Sections from spinal cord kuchaorva at 6-weeks after lysolecithin injection were evaluated for myeloid cell abundance by use of the EGFP marker green and immunolabeling for Iba-1 blue.
Role of macrophages in peripheral nerve injury and repair. Kucharova K, Stallcup WB NG2-proteoglycan-dependent contributions of oligodendrocyte progenitors and myeloid cells to myelin damage and repair. Myelin repair in NG2 null mice. Dissecting the multifactorial nature of demyelinating disease. Click here to view.
Kucharova K, Stallcup WB. Microglia are not able to substitute for macrophages in promoting OPC proliferation. This article has been cited by.
Michaela Kucharova – Tennis Explorer
Reproduced with permission from Kucharova and Stallcup, On the other hand, remyelination is retarded in both lines of NG2-null animals.
D—F Toluidine blue-stained TB semi-thin sections enabled identification of well-myelinated kuchsrova arrowheads and unmyelinated axons asterisks. In the absence of macrophage recruitment, OPC proliferation is greatly impaired, again leading to decreased generation of myelinating oligodendrocytes.
Neural Regen Res ; How to cite this URL: How to cite this article: Reproduced with permission from Kucharova K and Stallcup, Two types of CSPG4 manipulations have been used to study the roles of these cells in myelin damage and repair: Reiterer G, Yen A Platelet-derived growth factor receptor regulates myeloid and monocytic differentiation of HL cells.
Chondroitin sulfate proteoglycan-4 CSPG4 is a surface component of two key cell types oligodendrocyte progenitor cells OPCs and myeloid cells present in lysolecithin-induced lesions in mouse spinal cord. Trends Cell Mol Biol Kucharova K, Stallcup WB Distinct NG2 proteoglycan-dependent roles of resident microglia and bone marrow-derived macrophages during myelin damage and repair.
Ablation of CSPG4 in myeloid cells greatly decreases recruitment of macrophages to spinal cord lesions, resulting in smaller initial lesions, but also in significantly diminished myelin repair.
One hundred percent myelination is defined by the level of MBP labeling in sham-operated control mice. Franklin RJ Why does remyelination fail in multiple sclerosis?
Nat Rev Neurosci 3: